In Part 1, I described an experiment I am starting, first on myself in the spirit of self-experimentation, then on other volunteers. Before having my first session of plasma dilution, I got a bunch of markers measured to evaluate my condition before. Here is myself in data:
| Sample date | Biomarker | Value |
|---|---|---|
| 12/05/1986 | Sex | Male |
| 17/12/2020 | Chronological age | 34 years old |
| 15/06/2020 | Epigenetic age (mydnage.com, derivated from Horvath Original 2013) | 30 years old |
| 17/12/2020 | Epigenetic age (mydnage.com, derivated from Horvath Original 2013) | Waiting for data |
| 08/12/2020 | Levine’s Phenotypical age clock (blood) | 22 years old |
| 08/12/2020 | Haemoglobin | 143 g/L |
| 08/12/2020 | Haematocrit | 0.416 L/L |
| 08/12/2020 | Red Cell Count | 4.57 x10^12/L |
| 08/12/2020 | MCV | 91.2 fl |
| 08/12/2020 | MCH | 31.3 pg |
| 08/12/2020 | MCHC | 343 g/L |
| 08/12/2020 | RDW | 13.2% |
| 08/12/2020 | White Cell Count | 4.51 x10^9/L |
| 08/12/2020 | Neutrophils | 1.34 x10^9/L |
| 08/12/2020 | Lymphocytes | 2.69 x10^9/L |
| 08/12/2020 | Monocytes | 0.29 x10^9/L |
| 08/12/2020 | Eosinophils | 0.06 x10^9/L |
| 08/12/2020 | Basophils | 0.11 x10^9/L |
| 08/12/2020 | Platelet Count | 191 x10^9/L |
| 08/12/2020 | MPV | 12.3 fL |
| 25/11/2020 | Urea | 8.30 mmol/L |
| 25/11/2020 | Creatinine | 84 umol/L |
| 25/11/2020 | eGFR | 90.74 ml/min/1.73m2 |
| 25/11/2020 | Bilirubin | 6.60 umol/L |
| 25/11/2020 | ALP | 70.00 IU/L |
| 25/11/2020 | ALT | 20.60 IU/L |
| 25/11/2020 | GGT | 14.00 IU/L |
| 25/11/2020 | Total Protein | 68.30 g/L |
| 25/11/2020 | Albumin | 46.90 g/L |
| 25/11/2020 | Globulin | 21.4 g/L |
| 25/11/2020 | SHBG | 65.10 nmol/L |
| 25/11/2020 | HbA1c | 29.6 mmol/mol |
| 25/11/2020 | Total Cholesterol | 6.37 mmol/L |
| 25/11/2020 | LDL Cholesterol | 3.75 mmol/L |
| 25/11/2020 | Non HDL Cholesterol | 4.13 mmol/L |
| 25/11/2020 | HDL Cholesterol | 2.24 mmol/L |
| 25/11/2020 | Triglycerides | 0.84 mmol/L |
| 25/11/2020 | CRP HS | 0.65 mg/L |
| 25/11/2020 | Uric Acid | 281.00 umol/L |
| 25/11/2020 | Creatine Kinase | 101.00 IU/L |
| 25/11/2020 | Iron | 19.69 umol/L |
| 25/11/2020 | TIBC | 68.19 umol/L |
| 25/11/2020 | UIBC | 48.50 umol/L |
| 25/11/2020 | Transferrin Saturation | 28.88% |
| 25/11/2020 | Ferritin | 25.50 ug/L |
| 25/11/2020 | TSH | 2.93 mIU/L |
| 25/11/2020 | Free T3 | 3.61 pmol/L |
| 25/11/2020 | Free Thyroxine | 15.400 pmol/L |
| 25/11/2020 | FSH | 9.65 IU/L |
| 25/11/2020 | LH | 4.61 IU/L |
| 25/11/2020 | Oestradiol | 99.20 pmol/L |
| 25/11/2020 | Testosterone | 25.60 nmol/L |
| 25/11/2020 | Prolactin | 261.00 mU/L |
| 25/11/2020 | DHEA Sulphate | 5.420 umol/L |
| 25/11/2020 | Cortisol | 587.000 nmol/L |
| 25/11/2020 | Thyroglobulin Antibodies | <10 kIU/L |
| 25/11/2020 | Thyroid Peroxidase Antibodies | <9.0 kIU/ |
| 25/11/2020 | Blood Urea Nitrogen | 23.52 mg/dL |
| 25/11/2020 | Lipoprotein A | 105 nmol/L |
Now that we are ready, let’s go to the clinic.
I am pretty pleased with how it went. The doctor was interested in anti-aging research though not aware of the latest studies regarding plasma dilution. She has been doing this procedure for years and is very familiar with the risks and benefits. The regulations in France limit the quantity of plasma that can be replaced in one go to 800mL. However she found out that depending on the health of the patient, replacing double this dose is perfectly safe. Obviously she would never break the law, so she would never process more than 800mL, but if she did, hypothetically, she would remove a full 1600mL of plasma and replace it with a saline solution (NaCL 0.9%) and a few mL of Anticoagulant Citrate Dextrose-A as described in part 1.
The machine is a Hemofenix, russian made, but she was not able to give me the exact pore size, only that it was at most 80-100 nm. She will try to get the exact pore sizes.
My estimated plasma volume is 2630 mL according to this calculator and others. So I would hypothetically have had more than 60% of my plasma processed, though by the nature of the dilution process that would amount more to 50%. Pretty close to the study I’m trying to replicate!
The whole process took 75 minutes from start to finish.
I was able to keep the extracted plasma with me, to hopefully have more tests run on it.
As far as how I feel, there aren’t many sensations. You feel a few tingling sensations here and there, you’re a little bit tired for the rest of the day, but overall it’s pretty painless and uneventful. Which is good.
During the dilution, I chatted a bit with the doctor and she gave me a few very intriguing anecdotes: this 87 years old professor in Russia whose having wonderful results doing the procedure every month, this guy with a metastasized cancer having been “cured” with one 4-sessions procedure, herself and lot of other aged individuals getting a lot more energy after 1 procedure for months or years, and even this doctor in Spain having treated alzheimer patients for 6 years with very good results,… and so on and so on. This is just anecdotal data, and am not sure why there aren’t more published reports/studies if they are so good. But that’s why we’re here after all, aren’t we?
The next 2 sessions are on December 21 and 23, they will be run with the same protocol. One month after the last session, I will get new blood markers measured, as well as epigenetic age by mydnage.com.